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<p class="MsoNormal">Sehr geehrte Damen und Herren,<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><span lang="EN-GB">I wish you a happy, healthy and prosperous year 2023!<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB">I would like to introduce our company and to suggest our services to the Arabidopsis Functional Genomics Network.
</span><span lang="EN-US" style="mso-fareast-language:FR">BIOTEM is a European leading CRO in
<b>immunotechnologies</b> for more than 40 years, and thanks to its extensive know-how and a large panel of exclusive technologies, we offer
<b>custom-made solutions </b>for your<b> polyclonal and monoclonal antibody projects</b>.
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:FR"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US">Generating new antibodies</span></b><span lang="EN-US"> is the core of our activities, we are involved in research, diagnostic and therapeutic development projects.
</span><span lang="EN-US" style="mso-fareast-language:FR">We analyse your project to select the best strategy against your target depending on material available, required affinity, targeted epitope, cross-reactivity or specificity, etc. Please note that we
have a strong specialization in <b>polyclonal antibody development</b>. We use for monoclonal antibodies both the
<b>classical Hybridoma approach</b> as well as the <b>Phage Display technology</b>.<br>
Thereby we can develop <b>rabbit monoclonal antibodies</b> that are specially recognized for their great affinity (up to pM).<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:FR"> <o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:FR">I would be please to schedule a short videoconference meeting to discuss any question or project you might have.
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:FR">In the meantime, please find attached a PPT presentation of our services.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:FR"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:FR">Feel free to transfer this email and my contact details to any colleague interested in our activities!<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="color:#1F497D;mso-fareast-language:FR"> </span><span lang="EN-US" style="color:black;mso-fareast-language:FR"><o:p></o:p></span></p>
<p class="MsoNormal">I am looking forward to hearing from you.<span lang="EN-US" style="color:#1F497D;mso-fareast-language:FR"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="color:#1F497D;mso-fareast-language:FR"> <o:p></o:p></span></p>
<p class="MsoNormal">Mit freundlichen Grüßen,<br>
Quentin Sevat<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
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<p class="MsoNormal" style="line-height:105%"><span style="color:#1F497D;mso-fareast-language:FR"><img width="372" height="219" style="width:3.875in;height:2.2833in" id="Image_x0020_3" src="cid:image001.png@01D92BFC.5300BAD0"></span><span style="mso-fareast-language:FR"><o:p></o:p></span></p>
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<p class="MsoNormal" style="margin-left:7.05pt;line-height:105%"><span style="font-size:4.0pt;line-height:105%;font-family:"Arial",sans-serif;color:#1F3864;mso-fareast-language:FR"><br>
</span><b><span lang="EN-GB" style="font-family:"Arial",sans-serif;color:navy;mso-fareast-language:FR">Quentin SEVAT, MSc.</span></b><b><span lang="EN-GB" style="font-size:12.0pt;line-height:105%;font-family:"Times New Roman",serif;color:#1F497D;mso-fareast-language:FR"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-left:7.05pt;line-height:105%"><span lang="en-AE" style="font-size:4.0pt;line-height:105%;font-family:"Arial",sans-serif;color:#1F3864;mso-fareast-language:FR"><br>
</span><span lang="EN-GB" style="font-size:9.0pt;line-height:105%;font-family:"Arial",sans-serif;color:navy;mso-fareast-language:FR">Sales & Business Development<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.05pt;line-height:105%"><span lang="EN-GB" style="font-size:9.0pt;line-height:105%;font-family:"Arial",sans-serif;color:navy;mso-fareast-language:FR"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-left:7.05pt;line-height:105%"><span style="font-size:9.0pt;line-height:105%;color:#262626;mso-fareast-language:FR">Parc d’activités Bièvre Dauphine<br>
885 rue Alphonse Gourju<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.05pt;line-height:105%"><span style="font-size:9.0pt;line-height:105%;color:#262626;mso-fareast-language:FR">38140 Apprieu – France<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.05pt;line-height:105%"><b><span style="font-size:10.0pt;line-height:105%;color:#262626;mso-fareast-language:FR">Phone in Germany: +49 (0) 681 9963 227<o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-left:7.05pt;line-height:105%"><b><span style="font-size:10.0pt;line-height:105%;color:#262626;mso-fareast-language:FR">Commercial Switchboard in France:<br>
+33 (0) 476 939 735</span></b><span style="font-size:6.5pt;line-height:105%;font-family:"Arial",sans-serif;color:#8C8C8C;mso-fareast-language:FR"><br>
</span><span style="mso-fareast-language:FR"><a href="mailto:quentin.sevat@biotem.fr"><b><span style="font-size:10.0pt;line-height:105%;color:blue">quentin.sevat@biotem.fr</span></b></a></span><b><span style="font-size:10.0pt;line-height:105%;color:#262626;mso-fareast-language:FR"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-left:7.05pt;line-height:105%"><span style="mso-fareast-language:FR"><a href="http://www.biotem-antibody.com/"><span style="font-size:10.0pt;line-height:105%;color:blue">www.biotem-antibody.com</span></a></span><b><span style="font-size:12.0pt;line-height:105%;font-family:"Times New Roman",serif;color:#1F497D;mso-fareast-language:FR"><o:p></o:p></span></b></p>
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<p class="MsoNormal"><b><span lang="EN-GB" style="font-size:9.0pt;color:#2A166F"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span lang="EN-GB" style="font-size:9.0pt;color:#2A166F">BIOTEM OVERVIEW<o:p></o:p></span></b></p>
<p class="MsoNormal"><i><span lang="EN-US" style="font-size:9.0pt;color:#2A166F">As a CRO, expert in immunotechnologies for more than 40 years, BIOTEM provides fully customized and high added value services for the development of
<b>antibodies</b> and <b>immunoassays</b>. <o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span lang="EN-US" style="font-size:9.0pt;color:#2A166F">Today, thanks to its extensive know-how and a large panel of
<b>exclusive technologies</b>, BIOTEM successfully leads the most ambitious projects (> 96 % success rate) and can propose contracts with
<b>guaranteed results</b> (ask your contact at BIOTEM).<o:p></o:p></span></i></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><i><span lang="EN-US" style="font-size:9.0pt;color:#2A166F">As a CMO, BIOTEM offers the highest non-GMP quality for CHO productions with quantities beyond the gram. All services are available as
<b>100% fee-for-service</b> (No claims, no royalties and no follow-up rights) and are qualified
<b>ISO 9001</b> / <b>ISO 13485</b>.<o:p></o:p></span></i></p>
<p class="MsoNormal"><b><i><u><span lang="EN-US" style="font-size:9.0pt;color:#2A166F">Service offer:
<o:p></o:p></span></u></i></b></p>
<p class="MsoNormal"><b><i><u><span lang="EN-US" style="font-size:9.0pt;color:#2A166F"><o:p><span style="text-decoration:none"> </span></o:p></span></u></i></b></p>
<ul style="margin-top:0cm" type="disc">
<li class="MsoNormal" style="color:#2A166F;mso-list:l0 level1 lfo1"><b><i><u><span lang="EN-US" style="font-size:9.0pt;color:#EE8E00">Quinthetic Library™:</span></u></i></b><i><span lang="EN-US" style="font-size:9.0pt"> Recombinant antibodies from synthetic
libraries / Rapid process / Animal-free technology / High stability & focalized diversity</span></i><span lang="EN-US" style="font-size:9.0pt"><o:p></o:p></span></li><li class="MsoNormal" style="color:#2A166F;mso-list:l0 level1 lfo1"><b><i><u><span lang="EN-US" style="font-size:9.0pt;color:#EE8E00">Rabbit Monoclonal Antibodies (Phage Display):</span></u></i></b><i><span lang="EN-US" style="font-size:9.0pt"> Immune library
construction / Highest affinity antibodies / Optimal for small molecule detection / Novel epitope recognition</span></i><span lang="EN-US" style="font-size:9.0pt"><o:p></o:p></span></li><li class="MsoNormal" style="color:#2A166F;mso-list:l0 level1 lfo1"><b><i><u><span lang="EN-US" style="font-size:9.0pt;color:#EE8E00">Murine Monoclonal Antibodies (Hybridoma & Phage Display):</span></u></i></b><i><span lang="EN-US" style="font-size:9.0pt">
Exclusive technologies for low immunogenic targets / Small quantity of antigens / Short deadlines</span></i><span lang="EN-US" style="font-size:9.0pt"><o:p></o:p></span></li><li class="MsoNormal" style="color:#2A166F;mso-list:l0 level1 lfo1"><b><i><u><span lang="EN-US" style="font-size:9.0pt;color:#EE8E00">Therapeutic Antibodies (human and veterinary applications):</span></u></i></b><i><span lang="EN-US" style="font-size:9.0pt">
Diverse and exclusive technologies depending on project specification </span></i><span lang="EN-US" style="font-size:9.0pt"><o:p></o:p></span></li><li class="MsoNormal" style="color:#2A166F;mso-list:l0 level1 lfo1"><b><i><u><span lang="EN-US" style="font-size:9.0pt;color:#EE8E00">Antibody Production:</span></u></i></b><i><span lang="EN-US" style="font-size:9.0pt"> From Hybridoma & Recombinant Antibody
(Transient transfection in CHO cells) / Small & large scale antibody production
</span></i><span lang="EN-US" style="font-size:9.0pt"><o:p></o:p></span></li><li class="MsoNormal" style="color:#2A166F;mso-list:l0 level1 lfo1"><b><i><u><span lang="EN-US" style="font-size:9.0pt;color:#EE8E00">Antibody Sequencing and Engineering:</span></u></i></b><i><span lang="EN-US" style="font-size:9.0pt"> Humanization, Affinity
maturation, Several isotypes & formats (scFv-Fc, Fab, Full Ig, etc.)</span></i><span lang="EN-US" style="font-size:9.0pt"><o:p></o:p></span></li><li class="MsoNormal" style="color:#2A166F;mso-list:l0 level1 lfo1"><b><i><u><span lang="EN-US" style="font-size:9.0pt;color:#EE8E00">Polyclonal antibodies:</span></u></i></b><i><span lang="EN-US" style="font-size:9.0pt"> Custom & standard immunization protocols</span></i><span lang="EN-US" style="font-size:9.0pt"><o:p></o:p></span></li><li class="MsoNormal" style="color:#2A166F;mso-list:l0 level1 lfo1"><b><i><u><span lang="EN-US" style="font-size:9.0pt;color:#EE8E00">Immunoassay (LFIA & ELISA) Development:</span></u></i></b><i><span lang="EN-US" style="font-size:9.0pt"> Any matrix & analyte
/ Several applications (IVD medical devices, Human & animal health, Quality control, Environment, etc.</span></i><i><span lang="EN-US" style="font-size:9.0pt;color:#44546A">)</span></i><span lang="EN-US" style="font-size:9.0pt"><o:p></o:p></span></li><li class="MsoNormal" style="color:#2A166F;mso-list:l0 level1 lfo1"><b><i><u><span lang="EN-US" style="font-size:9.0pt;color:#EE8E00">Immunoassay Production:</span></u></i></b><i><span lang="EN-US" style="font-size:9.0pt;color:red">
</span></i><i><span lang="EN-US" style="font-size:9.0pt">Industrial Production from conditioned master sheets to immediately marketable kits</span></i><span lang="EN-US" style="font-size:9.0pt"><o:p></o:p></span></li><li class="MsoNormal" style="color:#2A166F;mso-list:l0 level1 lfo1"><b><i><u><span lang="EN-US" style="font-size:9.0pt;color:#EE8E00">Optimized Antibodies in IHC (FFPE tissues):</span></u></i></b><span lang="EN-US" style="font-size:9.0pt;color:windowtext">
</span><i><span lang="EN-US" style="font-size:9.0pt">Exclusive Technology IHC Peptide Profiler® / Available for Hybridoma & Phage Display</span></i><span lang="EN-US" style="font-size:9.0pt"><o:p></o:p></span></li></ul>
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